Potent GH20 N-acetyl-β-D-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5- hydroxymethyl-cyclopentanediols

Abstract

From 1, 2;3, 4-di-O-isopropylidene-D-galactopyranose, a preliminary series of highly functionalized amino(hydroxymethyl)cyclopentanes was easily available. These amine-containing basic carbasugars featuring the D-galacto configuration are potent inhibitors of the GH20 β-D-hexosaminidases probed and may bear potential as regulators of N-acetyl-D-hexosaminidase activities in vivo.