It is estimated that 12%-15% of sexually active couples are infertile. When broken down by gender, a male component can be identified approximately 50% of the time either in isolation or in combination with a female factor. Previous research in a US male fertility clinic analyzing 1430 patients identified causes of infertility from most to least common: varicocele, idiopathic, obstruction, female factor, cryptorchidism, immunologic, ejaculatory dysfunction, testicular failure, drug effects/radiation, endocrinology, and all others. However, despite recent technologic and diagnostic advances, idiopathic infertility remains a common diagnosis, with approximately 25% of patients not having an identifiable cause of infertility. Regardless, many recognizable causes of male infertility are treatable or preventable; thus, a keen understanding of these conditions is paramount. This chapter comprises an overview of etiologies of male infertility, divided into pre-testicular, testicular, and post-testicular causes.
CITATION STYLE
Machen, G. L., & Sandlow, J. I. (2020). Causes of Male Infertility. In Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants: Second Edition (pp. 3–14). Springer International Publishing. https://doi.org/10.1007/978-3-030-32300-4_1
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