Total synthesis of himastatin

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Abstract

The natural product himastatin has an unusual homodimeric structure that presents a substantial synthetic challenge. We report the concise total synthesis of himastatin from readily accessible precursors, incorporating a final-stage dimerization strategy that was inspired by a detailed consideration of the compound’s biogenesis. Combining this approach with a modular synthesis enabled expedient access to more than a dozen designed derivatives of himastatin, including synthetic probes that provide insight into its antibiotic activity.

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APA

D’Angelo, K. A., Schissel, C. K., Pentelute, B. L., & Movassaghi, M. (2022). Total synthesis of himastatin. Science, 375(6583), 894–899. https://doi.org/10.1126/science.abm6509

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