Toxicological investigation and antinociceptive property of potassium thiophene-3-trifluoroborate

Abstract

The aim of the present study was to evaluate pharmacological and toxicological properties of potassium thiophene-3-trifluoroborate (RBF 3K). The acute effect of RBF3K was evaluated on mice. To this end, mice received a single dose of RBF3K (25, 50, and 100 mg/kg, by oral route, p.o.) and after 72 hrs, blood, liver, and kidney samples were collected. δ-Aminolevulinate dehydratase, catalase and glutathione-S-transferase activities, thiobarbituric acid-reactive substances and vitamin C levels, as well as plasma aspartate and alanine aminotransferase activities and creatinine levels were determined. Hepatic and renal lipid peroxidation levels in treated mice did not differ from those in control mice. No significant differences between treated and control mice were detected in hepatic and renal δ-aminolevulinate dehydratase activity. Aspartate and alanine aminotransferase activities as well as urea and creatinine levels were similar among the groups. In contrast, results obtained from in vivo experiments revealed that RBF3K, orally administered, reduced peritoneovisceral pain induced by acetic acid administered i.p. Doses of 1, 5, 10, 25, 50, and 100 mg/kg of RBF3K were assessed in the antinociceptive investigation and the effect was sigificantly different than control groups from 5 mg/kg. It was observed that α2-adrenergic and serotonergic, but not opioidergic, receptors appear to be involved in orally administered RBF 3K. Mice treated with RBF3K did not reveal any motor impairment in the open field. This is a promising compound for more detailed pharmacological studies involving organotrifluoroborate compounds. © 2009 Nordic Pharmacological Society.