Partitial remission of pulmonary metastasis of malignant gonadal stromal tumor by salvage chemotherapy

Abstract

Fourteen malignant cases of gonadal stromal tumor were found among the cases reported in literature, but the roles of chemotherapy and radiotherpy have not been defined. We treated a malignant case and achived 98.9per-cent remission of lung metastases by salvage chemotherapy (cis-platinum+VP-16). A 34 year-old desk-worker, underwent left orchiectomy for testicular tumor on March 20, 1984. Histologic examination showed a malignant gonadal stromal tumor invading into the epididymis. Three course of adjuvant chemotherapy with cis-platinum, vinblastin, and peplomycin (PVP) were performed. However, chest X-ray films 13 months later revealed multiple lung metastases. Although 3 courses of combination chemotherapy with cyclophosphamide, adriamycin, vincristine, and predonisolone (CHOP) were given, no remission was obtained. However following 4 courses of combination chemotherapy with cis-platinum and VP-16, 98.9per-cent remission of lung metatases was achieved. Subsequent bilateral residual lung tumors were resected. However, lung metastases recurred 3 months later, and the patient died on Feburary 29, 1988. The autopsy revealed extensive lung, liver and pancreas metatases, but no lymph node metastases. © 1989, THE JAPANESE UROLOGICAL ASSOCIATION. All rights reserved.