Protein Engineering Methods to Design Protein Therapeutics

Abstract

The expeditious growth of modern medicine has proven to be indispensable for protein therapeutics. In some instances, protein therapeutics are the only known cure. Continuous efforts have been put in to enhance their production and efficacy. The advancement of protein engineering methods has aided in developing effective protein therapeutics with increased affinity, pharmacokinetics, pharmacodynamics, immunogenicity, and productivity. In terms of novel protein therapeutic platform technologies, different synthetic protein scaffolds are in the early phases of clinical trials. Protein therapeutics have immense potential to improve human health. As protein engineering efforts have grown and diversified, understanding the biophysical and biochemical properties of proteins and applying this information to developing effective pharmacological medications has become increasingly relevant. The overall purpose of the various methodologies for designing protein therapeutics is to better understand their role in medicine for proper care and diagnosis, leading to further innovation and development.