Association of serum omentin-1 levels with coronary artery disease

Abstract

Aim: Omentin-1, a novel adipokine expressed in visceral adipose tissue, is negatively correlated with insulin resistance and obesity. Decreased omentin-1 expression has been found in many chronic inflammatory diseases. However, the role of omentin-1 in coronary artery disease (CAD) has not been elucidated. The aim of the present study was to determine whether serum concentration of omentin-1 was independently associated with CAD. Methods: One hundred and fifty five patients with CAD were divided into two groups: acute coronary syndrome (ACS) and stable angina pectoris (SAP). A total of 52 healthy participants served as controls. Serum concentrations of omentin-1 and interleukin-6 (IL-6) were measured using ELISA. The association of omentin-1 with CAD and cardiovascular disease risk factors was evaluated. Results: Serum omentin-1 levels were lower in patients with ACS or SAP compared with controls (ACS, 113.08±61.43 ng/mL; SAP, 155.4±166.89 ng/mL; control, 254.00±72.9 ng/mL; P0.01). Patients with ACS also had lower serum concentrations of omentin-1 compared with patients with SAP (P0.01). Serum concentration of omentin-1 was negatively correlated with body mass index (r=0.17, P0.05) and serum IL-6 concentration (r=0.19, P0.05). Furthermore, multiple logistic regression analysis showed that serum omentin-1 concentrations were independently correlated with CAD. Conclusion: The findings suggest that serum concentrations of omentin-1 are related to CAD. © 2011 CPS and SIMM All rights reserved.