Comparison of K-ras mutations in lung, colorectal and gastric cancer

13Citations
Citations of this article
19Readers
Mendeley users who have this article in their library.

Abstract

K-ras is involved in the EGFR pathway that regulates cell survival, motility and proliferation, as well as angiogenesis and metastasis. It is also essential for carcinogenesis. The K-ras mutation status can be used to predict the therapeutic efficacy of targeted drugs such as cetuximab. The aim of this study was to compare K-ras mutation in different types of cancer. Nested and COLD-PCR were used to detect K-ras mutations. The Chi-squared test was used for statistical analysis. In this study, the total K-ras mutation frequency was found to be 9.09, 18.61 and 6.67% in lung, colorectal and gastric cancer, respectively. Similar K-ras mutation frequencies were detected among sample types and genders for lung and gastric cancer, with the exception of colorectal cancer. However, age had no impact on the K-ras mutation rates.

Cite

CITATION STYLE

APA

Peng, N., & Zhao, X. (2014). Comparison of K-ras mutations in lung, colorectal and gastric cancer. Oncology Letters, 8(2), 561–565. https://doi.org/10.3892/ol.2014.2205

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free