Disposition Kinetic of Moxifloxacin following Intravenous, Intramuscular, and Subcutaneous Administration in Goats

Abstract

The present study was carried out to investigate disposition kinetics of moxifloxacin following single-dose intravenous (i.v.), intramuscular (i.m.), and subcutaneous (s.c.) administration at a dose rate of 5 mg/kg of body weight (b.wt.) in goats. Plasma samples collected after treatments were analyzed for drug concentration using high-performance liquid chromatography (HPLC). After i.v. administration, distribution of the drug was rapid and wide as reflected by high steady-state volume of distribution. Drug elimination was relatively faster with a total body clearance of 0.59 ± 0.03 L/h/kg. Following i.m. injection, the drug has shown the rapid and near-to-complete absorption with bioavailability of 98.20 ± 3.96 per cent. The maximum plasma drug concentration ( C max ) of 1.21 ± 0.04 μg/mL was attained at 1 h ( T max ). The drug was widely distributed as reflected by high apparent volume of distribution. The elimination half-life ( t 1 / 2 β ) of the drug was 6.26 ± 0.08 h. Following s.c. administration, the drug was rapidly absorbed ( C max : 1.16 ± 0.02 μg/mL; t max : 1 h) and slowly eliminated from the body. The elimination half-life and total body clearance ( Cl B ) were 5.61 ± 0.10 h and 0.60 ± 0.03 L/h/kg, respectively. The bioavailability of moxifloxacin following s.c. administration was 90.44 ± 3.96 per cent.