Various expressions related to the length of a conserved haplotype around a polymorphism of known frequency are derived. We obtain exact expressions for the probability that no recombination has occurred in a sample or subsample. We obtain an approximation for the probability that no recombination that could give rise to a detectable recombination event (through the four-gamete test) has occurred. The probabilities can be used to obtain approximate distributions for the length of variously defined haplotypes around a polymorphic site. The implications of our results for data analysis, and in particular for detecting selection, are discussed.
Mendeley helps you to discover research relevant for your work.
CITATION STYLE
Innan, H., & Nordborg, M. (2003). The extent of linkage disequilibrium and haplotype sharing around a polymorphic site. Genetics, 165(1), 437–444. https://doi.org/10.1093/genetics/165.1.437