Animal models of spondyloarthritis

Abstract

Animal models are available for the studyof several different aspects of spondyloarthritis. The models include naturally occurring spontaneous disorders in primates and rodents, spon taneous disorders in transgenic or gene-deleted rodents and induced disorders inrodents. Areas ofinvestigation to which these models contribute include the role HLA-B27,processes of spinal and peripheral joint inflammation and calcification, immune responsesto candidate antigens and the role of TNF. © 2009 Landes Bioscience and Springer Science-s-Business Media.