Effect of Correlated tRNA abundances on translation errors and evolution of codon usage bias

60Citations
Citations of this article
159Readers
Mendeley users who have this article in their library.

Abstract

Despite the fact that tRNA abundances are thought to play a major role in determining translation error rates, their distribution across the genetic code and the resulting implications have received little attention. In general, studies of codon usage bias (CUB) assume that codons with higher tRNA abundance have lower missense error rates. Using a model of protein translation based on tRNA competition and intra-ribosomal kinetics, we show that this assumption can be violated when tRNA abundances are positively correlated across the genetic code. Examining the distribution of tRNA abundances across 73 bacterial genomes from 20 different genera, we find a consistent positive correlation between tRNA abundances across the genetic code. This work challenges one of the fundamental assumptions made in over 30 years of research on CUB that codons with higher tRNA abundances have lower missense error rates and that missense errors are the primary selective force responsible for CUB. © 2010 Shah, Gilchrist.

Cite

CITATION STYLE

APA

Shah, P., & Gilchrist, M. A. (2010). Effect of Correlated tRNA abundances on translation errors and evolution of codon usage bias. PLoS Genetics, 6(9). https://doi.org/10.1371/journal.pgen.1001128

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free