Synthesis and application of chiral triazine condensing reagents prepared from esters of amino acids

Abstract

Treatment of cyanuric chloride with chiral amines or esters of chiral amino acids gave chiral 2,4-dichloro-6-alkylamino-1,3,5-triazines (2-5) in 49-69% yield, which were found useful as coupling reagents. Enantioselective activation and enantio-selective aminolysis in the presence of 2-5 was observed.