Gangliosides, a complex group of cell-surface sialoglycosphingolipids particularly abundant in neuronal tissues, are assumed to be involved in a variety of cell-surface events, such as synaptogenesis, regulation of cell-growth, neuronal regeneration (for review see Ledeen, 1984), and, last but not least, synaptic transmission (Rahmann, 1983; Wieraszko and Siefert, 1986). Indeed, some investigators have suggested that exogenous gangliosides promote structural repair after brain lesions in vivo (Sabel et al., 1984; Toffano et al., 1983), which may have implications for recovery of function (Dunbar et al., 1986). The facilitated recovery may be due as well to a reduction in neuronal cell loss and axonal/dendritic degeneration and a subsequent neuronal regeneration or both together (Karpiak et al., 1986). Nevertheless, the molecular events that underlie these effects remain unexplained.
CITATION STYLE
Schenk, H., Haselhorst, U., Uranova, N. A., Krusche, A., Hantke, H., & Orlovskaja, D. D. (1990). Gangliosides, Learning, and Behavior. In Machinery of the Mind (pp. 323–336). Birkhäuser Boston. https://doi.org/10.1007/978-1-4757-1083-0_16
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