Circadian rhythm and pain: Mathematical model based on multiagent simulation

Abstract

The circadian rhythm controls the unconscious activities of living beings through the biological clock. External influences, such as pain, migraine, depression or anxiety, cause dysfunction in the synchronization and desynchronization of the human body. We propose to study the mathematical and computational properties that can describe the modeling of circadian rhythm, specifically with the influence of pain. We use a mathematical model of two processes, composed of circadian and homeostatic rhythms. The computational model, via a multiagent system, will use the pain variable, that will define by a non-invasive questionnaire with people. Preliminary results show that pain directly influences the quality of sleep, as well as the development of daily activities.