Efficacy of eosin B as a new antimalarial drug in a murine model

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Abstract

The initial success of any adopted anti-infective strategy to malaria is followed by a descent due to the emergence of resistance to it. The search for new drugs and drug targets is a consistent demand in this disease. Eosin B, a common laboratory dye, is reported to have good antiparasitic properties in vitro. It was studied for its antiparasitic effect in vivo on chloroquine-sensitive Plasmodium berghei murine malaria. Eosin B was administered in 2 different doses by either the oral or parenteral route, once or twice daily to mice infected with Plasmodium berghei. Both the doses of eosin B 400 mg/kg and 800 mg/kg gave better results than the controls which were 40 mg/kg chloroquine and 100 mg/kg of arteether with P<0.005 significance. Percentage suppressive activity by Peter's test of eosin B was better, though at a higher dose than both the controls. Survival rate of mice receiving the higher dose of eosin B was longer than that of the controls. When administered twice daily, the mice were fully cured after 4 days. Eosin B seems to be a promising drug exhibiting good antimalarial effects in the murine model of the disease. © 2012 Zahra Zamani et al.

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Zamani, Z., Tafreshi, A. S., Nahrevanian, H., Lame-Rad, B., Pourfallah, F., Eslamifar, H., … Arjmand, M. (2012). Efficacy of eosin B as a new antimalarial drug in a murine model. Malaria Research and Treatment, 2012. https://doi.org/10.1155/2012/381724

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