The Sedative Effect of Propofol and Midazolam in Pediatric Caudal Anesthesia

Abstract

Pediatric patients often could not be cooperated with physician during various procedures. So, many agents such as inbalation anesthetics and intravenous anesthetics have been used to decrease pain, anxiety and awareness during regional anesthesia in children. The purpose of this study was to compare propofol with midazolam and inhalation anesthetics for emergence time from sedation in caudal anesthesia of children. Forty five patients were randomly divided three groups. In propofol group (Group P, n=15), induction dose of 1.0 mg/kg propofol (Diprivan) was received followed by continuous infusion of 3~5 mg/kg/hr. In midazolam group (Group M, n=15), induction dose of 0.15 mg/kg midazolam (Dormicum) was received followed by continuous infusion of 0.06~0.08 mg/kg/hr. In inhalation anesthetic group (Group E, n=15), O2‐NO2‐Enflurane (3L/min, 3L/min, 0.6~1.0 vo1% respectively) inhalated through face mask by non‐rebreathing system for sedation. The blood pressure, heart rate, arterial oxygen saturation during anesthesia and emergence time, complications were measured. The results were as follows: 1) The blood pressure was significantly decreased in group M and E. Heart rate was also significantly increased in group M and E. 2) The arterial oxygen saturation was not significantly changed in each three groups. 3) In the group P and E, emergence time was shorter than in the group M. From the above results, we conclude that propofol is more excellent intravenous anesthetics than midazolam in respect to emergence time and hemodynamic changes in pediatric caudal anesthesia. [By kind permission, KoreaMed, Korean Association of Medical Journal Editors.]