UJI EFEK EKSTRAK ETANOL UMBI TALAS HISTOPATOLOGI GINJAL TIKUS PUTIH JANTAN (Rattus norvegicus) DIINDUKSI STREPTOZOTOCIN

Abstract

Diabetes mellitus is a systemic disease or metabolic syndrome caused by chronic disorders, especially in the body's carbohydrate, fat, and protein metabolism system. This study aims to determine the content of secondary metabolites of alkaloids, flavonoids, saponins, and tannins in the ethanolic extract of taro tubers and determine the effect and effective dose of the extract on the regeneration of kidney organ cells in streptozotocin-induced rats. Rats were divided into five groups: normal control, negative control, and extract treatment groups at doses of 100, 200, and 300 mg/kg BW that were performed for 28 days. This study observed changes that occurred in the renal tubular cells of white male rats induced by streptozotocin in the form of the level of damage with a value calculated based on the percentage (%) in each part of the tubule that was injured or damaged. The results showed that the taro tuber extract contained positive secondary metabolites of alkaloids, flavonoids, saponins, and tannins. Administration of ethanol extract of taro tubers at a dose of 300 mg/kg BW can affect the regeneration of kidney tubule cells in STZ-induced rats, with an average damage value of 1 out of a maximum of 4.