Growing bacteria shed elicitors of Drosophila humoral immunity

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Abstract

It has been much debated how the Drosophila immune system can recognize bacterial peptidoglycan that is often hidden. We show that bacteria separated from Drosophila S2 cells by a semipermeable membrane can upregulate the Imd pathway. Supernatants from exponentially growing but not from stationary-phase bacterial cultures induce antimicrobial peptides. It is also made likely that the shed elicitors are of peptidoglycan nature. Copyright © 2011 S. Karger AG, Basel.

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Karlsson, J., Oldenvi, S., Fahlander, C., Daenthanasanmak, A., & Steiner, H. (2011). Growing bacteria shed elicitors of Drosophila humoral immunity. Journal of Innate Immunity, 4(1), 111–116. https://doi.org/10.1159/000329224

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