Ethanolic whole plant extract of farsetia jacquemontii showed antipyretic & analgesic potential in mice

Abstract

To evaluate the analgesic and antipyretic activities of ethanolic whole plant extract of Farsetia jacquemontii (EWFJ) in mice. The plant is the habitat of Rajasthan & Northwestern parts of India. In folk system of medicine, it is known as “Farid-booti”, used traditionally in rheumatism, constipation, piles & abdominal pain. An-tipyretic activity was assessed against Brewer’s yeast induced pyrexia in mice using paracetamol (100 mg/kg) as standard. Analgesic activity was determined against hot plate & acetic acid induced writhing method in mice using diclofenac sodium (10 mg/kg) as standard. EWFJ (400 mg/kg) showed significant antipyretic effect after 2 hours of treatment when compared with standard paracetamol (100 mg/kg) in Brewer’s yeast induced pyrexia model. EWFJ (400 mg/kg) reduced reaction time after 3 hours of treatment in the same manner as with standard diclofenac sodium (10 mg/kg) against hot plate method. EWFJ (400 mg/kg) showed the effect in simi-lar manner as diclofenac sodium (10 mg/kg) against acetic acid induced writhing test. The study concluded antipyretic & analgesic effect of Farsetia jacquemontii.