The early expressed HIV-1 genes regulate DNMT1 expression

47Citations
Citations of this article
39Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

DNA methylation-mediated transcriptional regulation is essential for human development and diverse diseases ensue when this process is dysregulated. Viruses, including HIV-1, alter the expression of human DNA methyltransferases (DNMTs) and various T cell-specific genes. Here we show that HIV-1 induction of DNMT1 results from overexpression of the early expressed HIV-1 proteins, and this induction is prevented with resveratrol which interferes with the transcription factor AP1 pathway. The HIV-1 responsive element resides in the 5' most 420 bp of the -1634 to +71 DNMT1 promoter; positioning of this truncated promoter proximal to a hybrid SV40-DNMT1 reporter results in HIV-1-dependent regulation. HIV-1 mediated induction of DNMT1 is not specific to T-cells, and does not require receptor-mediated endocytosis. The characterization of HIV-1 mediated DNMT1 regulation provides a basis for identifying viral and cellular factors necessary for the de novo DNA methylation of cellular genes. © 2008 Landes Bioscience.

Author supplied keywords

References Powered by Scopus

The fundamental role of epigenetic events in cancer

4942Citations
N/AReaders
Get full text

Epigenetics in human disease and prospects for epigenetic therapy

2742Citations
N/AReaders
Get full text

Cancer chemoprevention with dietary phytochemicals

2629Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Genetic and epigenetic mechanisms in thyroid autoimmunity

115Citations
N/AReaders
Get full text

Cutting edge: The etiology of autoimmune thyroid diseases

96Citations
N/AReaders
Get full text

Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer

80Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Youngblood, B., & Reich, N. O. (2008). The early expressed HIV-1 genes regulate DNMT1 expression. Epigenetics, 3(3), 149–156. https://doi.org/10.4161/epi.3.3.6372

Readers over time

‘11‘12‘13‘14‘15‘16‘18‘19‘20‘21‘22‘23‘2402468

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 16

53%

Professor / Associate Prof. 7

23%

Researcher 7

23%

Readers' Discipline

Tooltip

Immunology and Microbiology 9

36%

Biochemistry, Genetics and Molecular Bi... 7

28%

Agricultural and Biological Sciences 6

24%

Medicine and Dentistry 3

12%

Save time finding and organizing research with Mendeley

Sign up for free
0