Superoxide triggers an acid burst in saccharomyces cerevisiae to condition the environment of glucose-starved cells

Abstract

Background: During prolonged periods without glucose yeast cells acidify the extracellular environment. Results: This acid burst is derived from a mitochondrial aldehyde dehydrogenase and a cascade involving superoxide damage to the TCA cycle. Conclusion: The acid burst can condition the medium to improve cell growth. Significance: Damage from mitochondrial superoxide can be advantageous to cells during carbon starvation stress.© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.