Palladium-Catalyzed Reactions of Terminal Acetylenes and Olefins with Halo-1,3-azoles

Abstract

The palladium-catalyzed reactions of 4-bromo- and 5-bromothiazoles, as well as 4-bromo- and 5-bromooxazoles with terminal acetylenes gave ethynyl derivatives in 43—89% yields, whereas the reactions of 2-bromothiazoles and iodo-N-methylimidazoles afforded the products in poor yields. The reaction of the halo-1,3-azoles with terminal olefins was also examined. © 1987, The Pharmaceutical Society of Japan. All rights reserved.