Polysaccharides from agaricus blazei stimulate lymphocyte T-cell subsets in mice

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Abstract

Subset analysis of splenic lymphocytes using flow cytometry showed that the percentages of Thy1.2-(pan T-cells), L3T4-(CD4, helper T-cells), and Lyt2-(CD8, cytotoxic T-cells) positive cell populations were significantly increased in mice orally administered a hot water-soluble fraction from Agaricus blazei as compared with mice treated only with saline. 13C-NMR data indicates that the main component in the active polysaccharide is the complex of α-1,6- and α-1,4-glucan, which had already been shown to have anti-tumor activity against Sarcoma 180. It seems that the polysaccharide from Agaricus blazei may be an effective prophylactic, protecting humans against cancer by stimulating lymphocytes such as cytotoxic T-cells. © 1998, Taylor & Francis Group, LLC. All rights reserved.

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Mizuno, M., Morimoto, M., Minato, K. I., & Tsuchida, H. (1998). Polysaccharides from agaricus blazei stimulate lymphocyte T-cell subsets in mice. Bioscience, Biotechnology and Biochemistry, 62(3), 434–437. https://doi.org/10.1271/bbb.62.434

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