Chromosome conformation capture technology and its derivatives have been widely used to study genome organization. Among them, Hi-C (chromosome conformation capture coupling with high-throughput sequencing) is popular in dissecting chromatin architecture on the genome-wide level. However, the intrinsic limitations prevent its application when it comes to rare samples. Here, we present easy Hi-C, a biotin-free technology that dramatically reduces DNA loss and is suitable for low-input samples.
CITATION STYLE
Lu, L., & Jin, F. (2023). Easy Hi-C: A Low-Input Method for Capturing Genome Organization. In Methods in Molecular Biology (Vol. 2599, pp. 113–125). Humana Press Inc. https://doi.org/10.1007/978-1-0716-2847-8_9
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