Correlating Circulating Vitamin D3 with Aspects of the Metabolic Syndrome and Nonalcoholic Fatty Liver Disease in Healthy Female Volunteers

Abstract

Background: Significant inverse correlations between circulating vitamin D3 and the presence and strength of common clinical entities influenced by insulin resistance (IR) have been reported. Among these entities are common maladies such as the metabolic syndrome (MS) and nonalcoholic fatty liver disease (NAFLD). Since hypovitaminosis D3 is considered a common worldwide health disturbance, the consequences emanating from such relationships once soundly established might reasonably be ameliorated by vitamin replacement. Accordingly, a need exists for definitive confirmatory support for the existence of these linkages particularly in ordinary, relatively healthy individuals. Methodology: Many aspects of MS and NAFLD were examined in healthy females via linear regression analyses to determine significant correlations mainly using vitamin D3 and fasting blood glucose (FBG), the latter a surrogate for IR, as independent variables. Results: A descending linear regression between vitamin D3 and FBG did not reach full statistical significance, but a negative correlation of vitamin D3 with HbA1C was statistically significant and that with circulating insulin concentrations showed a downward statistical trend. These findings are consistent with previous ones by others suggesting an ameliorating effect of vitamin D3 on IR. Body weight, body mass index (BMI), and body fat correlated statistically significantly with vitamin D3 levels, as did systolic blood pressure. Again, these correlations were negative instead of positive unlike the case when FBG was the independent variable. The significant negative correlation of ALT with vitamin D3 was also consistent with previous reports that higher circulating vitamin D3 favorably influences the extent and intensity of NAFLD. Conclusions: Employing FBG as a surrogate for IR and ALT for status of NAFLD, linear correlations reasonably suggest that increasing circulating vitamin D3 can favorably influence the initial development of and/or strength of risk factors for MS including NAFLD in relatively fit females.