[81F]Fluoromisonidazole ([ ([81F]FMISO) is a hypoxia imaging marker utilized in positron emission tomography. Novel FMISO precursors were prepared from a commercially available material, and several reaction factors that affect synthesis of [ [81F]FMISO were examined to achieve a higher fluorination yield. [18 F]FMISO was obtained from radiosynthesis, followed by the hydrolysis of protecting groups with HCl. New 2-nitroimidazole precursor showed a higher [18 F]fluorination and a higher synthetic yield. This result provided alternative guidelines for the preparation of hypoxia imaging marker.
CITATION STYLE
Kwon, Y. D., Jung, Y., Lim, B. S. T., Sohna, M. H., & Kim, H. K. (2016). Facile and efficient synthesis of [18 F]Fluoromisonidazole using novel 2-nitroimidazole derivatives. Journal of the Brazilian Chemical Society, 27(7), 1150–1156. https://doi.org/10.5935/0103-5053.20160010
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