An efficient synthesis of 2H-1,4-benzoxazin-3(4H)-ones via Smiles rearrangement

Abstract

A novel and effective synthesis of substituted 1,4-benzoxazinones via Smiles rearrangement is described. Treatment of N-substituted 2-chloroacetamide, substituted 2-chlorophenols and cesium carbonate in refluxing DMF afforded the corresponding substituted 1,4-benzoxazinones in excellent yield. ©ARKAT USA, Inc.