Sphingosomes: A Novel Vesicular Drug Delivery System

Abstract

Sphingosomes are bilayer vesicles, primarily made of natural or synthetic  sphingolipids, that completely surround an aqueous volume. Sphingosomes  address the main issues with vesicle systems (liposomes, niosomes),  including their lack of stability, short in vivo circulation times, and poor  tumour loading efficacy in cancer therapy. Sphingosomes are a promising  vesicular drug delivery system that can transport therapeutic chemicals for  a variety of potential applications, according to the review's findings. The  development of novel medication delivery systems has received a lot of  attention in recent decades (NDDS). To begin, it should administer the  medication at a pace determined by the body's requirements throughout the  course of therapy. Second, it must direct the active entity to the action  location. None of these can be met by conventional-dose forms, including  extended-release dosage forms. No existing drug delivery system now acts  optimally, although genuine efforts have been made to accomplish them via  different new drug delivery methods.1-5