Abstract
After decades of successful clinical use the exact molecular mechanisms by which the anti-resorptive bisphosphonate drugs BPs) exert their effects are now being revealed. In addition to their anti-resorptive effects it is now apparent that nitrogen-containing BPs N-BPs) have immunomodulatory properties. Specifically these drugs activate immune cells called gamma delta T lymphocytes. In this chapter we discuss the mechanism of gamma delta T cell activation by N-BPs and propose that N-BPs may provide a safe and effective means for manipulating gammadelta T cell activity in future immunotherapeutic approaches. © 2010 Springer Science+Business Media LLC.
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Thompson, K., Roelofs, A. J., Jauhiainen, M., Mönkkönen, H., Mönkkönen, J., & Rogers, M. J. (2010). Activation of γΔ T cells by bisphosphonates. In Advances in Experimental Medicine and Biology (Vol. 658, pp. 11–20). https://doi.org/10.1007/978-1-4419-1050-9_2
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