The effect of mangosteen (garcinia mangostana) pericarp extract on retinoblastoma cell culture proliferation

Abstract

Background To determine the effects of mangosteen (Garcinia mangostana) pericarp extracts on retinoblastoma cell culture proliferation. Methods This study was a true experimental in vitro design with a pre- and post-test control group. Retinoblastoma cell cultures were exposed to mangosteen pericarp extract (Garcinia mangostana) at doses of 10 μg/ml, 20 μg/ml, and 40 μg/ml. Results The retinoblastoma cell line cultures were obtained from the American Type Culture Collection (ATCC). The samples were divided into four groups: A control group and three groups treated with 10 μg/ml, 20 μg/ml, and 40 μg/ml, respectively, of mangosteen pericarp extract. The samples were then incubated for 48 hours and examined using an MTT cell proliferation assay. Group 1 (10 μg/ml) showed a decrease of 151.8%, group 2 (20 μg/ml) showed a decrease of 134.6%, and group 3 (40 μg/ml) showed a decrease of 134.36%. Conclusion Mangosteen pericarp extract (Garcinia mangostana) can reduce retinoblastoma culture cell proliferation.