The beta-globin genes have become a classical model for studying regulation of gene expression. Wide-ranging studies have revealed multiple levels of epigenetic regulation that coordinately ensure a highly specialised, tissue- and stage-specific gene transcription pattern. Key players include cis-acting elements involved in establishing and maintaining specific chromatin conformations and histone modification patterns, elements engaged in the transcription process through long-range regulatory interactions, transacting general and tissue-specific factors. On a larger scale, molecular events occurring at the locus level take place in the context of a highly dynamic nucleus as part of the cellular epigenetic programme.
CITATION STYLE
Chakalova, L., Carter, D., Debrand, E., Goyenechea, B., Horton, A., Miles, J., … Fraser, P. (2005). Developmental regulation of the beta-globin gene locus. Progress in Molecular and Subcellular Biology. https://doi.org/10.1007/3-540-27310-7_8
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