Nicotinamide adenine dinucleotide (NAD+) is a vital molecule found in all living cells. NAD+ intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate. The regulation of NAD+ metabolism has proven to be an adequate drug target for several diseases, including cancer, neurodegenerative or inflammatory diseases. Increasing interest has been given to NAD+ metabolism during innate and adaptive immune responses suggesting that its modulation could also be relevant during host-pathogen interactions. While the maintenance of NAD+ homeostatic levels assures an adequate environment for host cell survival and proliferation, fluctuations in NAD+ or biosynthetic precursors bioavailability have been described during host-pathogen interactions, which will interfere with pathogen persistence or clearance. Here, we review the double-edged sword of NAD+ metabolism during host-pathogen interactions emphasizing its potential for treatment of infectious diseases.
CITATION STYLE
Mesquita, I., Varela, P., Belinha, A., Gaifem, J., Laforge, M., Vergnes, B., … Silvestre, R. (2016, March 1). Exploring NAD+ metabolism in host-pathogen interactions. Cellular and Molecular Life Sciences. Birkhauser Verlag AG. https://doi.org/10.1007/s00018-015-2119-4
Mendeley helps you to discover research relevant for your work.