Anti-laminin-gamma 1 pemphigoid with generalized pustular psoriasis and psoriasis vulgaris

Abstract

Anti-p200 pemphigoid was first described in 1996 (1, 2) as a subepidermal blistering disorder characterized by auto-antibodies against a 200-kDa protein (p200) of the basement membrane zone (BMZ). In 2009, 90% of anti-p200 pemphigoid sera were reported to react with laminin γ1 (3). Approximately 30% of published cases of anti-laminin γ1 pemphigoid are associated with psoriasis vulgaris (PV) (4, 5), although the coexistence of anti-laminin γ1 pemphigoid and generalized pustular psoriasis (GPP) is rare. We describe here a rare case of anti-laminin γ1 pemphigoid with GPP plus PV in which no IL36RN or CARD14 mutations were identified.