Stellate cells: Synaptic processing and plasticity

Abstract

Stellate and basket cells in the molecular layer of the cerebellum are inhibitory interneurons which control the activity of Purkinje cells. Recent studies using genetic approaches have revealed the important function of these interneurons during behavioral tasks, motor coordination, and motor learning. Synaptic transmission onto cerebellar interneurons and interneuron inhibition onto Purkinje cells can be dynamically regulated by synaptic activity. The capacity of molecular layer interneurons to undergo activity-dependent changes in synaptic transmission and membrane excitability provides a cellular mechanism that underlies cerebellar learning and memory.