Nuclear inositides have a specific subcellular distribution that is linked to specific functions; thus their regulation is fundamental both in health and disease. Emerging evidence shows that alterations in multiple inositide signalling pathways are involved in pathophysiology, not only in cancer but also in other diseases. Here, we give an overview of the main features of inositides in the cell, and we discuss their potential as new molecular therapeutic targets.
CITATION STYLE
Follo, M. Y., Ratti, S., Manzoli, L., Ramazzotti, G., Faenza, I., Fiume, R., … Cocco, L. (2020). Inositide-dependent nuclear signalling in health and disease. In Handbook of Experimental Pharmacology (Vol. 259, pp. 291–308). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/164_2019_321
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