Insights into Behçet's disease

3Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.

Abstract

Behçet's disease is a chronic relapsing multi-organ inflammatory disorder characterized as a triad of oral and genital ulcers, uveitis. Characteristic manifestations of Behçet's disease are joints, skin, central nervous system and gastrointestinal tract involvement. Behçet's disease has a complicated genetic etiology. However, epidemiological studies recommend that genetic factors have a significant role in its pathogenesis, the same as other autoinflammatory disorders. Antigenic stimuli, antigen-presenting cells, T cells, monocyte, neutrophil and endothelial cells are most important parts of the pathology of the disease. Inflammatory response was triggered by an infectious agent in a genetically susceptible host. Understanding the pathogenesis based on the molecular mechanism of the disease highlights the new therapeutic modalities. Enhanced inflammatory activity and over-expression of proinflammatory cytokines are the striking features of Behçet's disease, and they are accordant with the result in other auto inflammatory disorders. Moreover, there is evidence of antigen-driven immune response in Behçet's disease, but it probably advances in further innate immune reactivity. New therapeutic modalities target specific and nonspecific suppression of the immune system. The diagnosis is a clinical one, and although there is no single laboratory test enough for the diagnosis of Behçet's disease. In this paper, a new aspect of the studies on genetic susceptibility, immunopathogenesis of Behçet's disease and novel treatment modalities will be discussed.

Cited by Powered by Scopus

Interleukin-17 in human inflammatory diseases

148Citations
N/AReaders
Get full text

Prevalence of ocular manifestations in systemic sclerosis patients

52Citations
N/AReaders
Get full text

Cytokine signatures of human whole blood for monitoring immunosuppression

11Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Shahneh, F. Z., Babalo, Z., Baradaran, B., & Sepehr, K. S. (2012). Insights into Behçet’s disease. Postepy Dermatologii i Alergologii. https://doi.org/10.5114/pdia.2012.32395

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 2

50%

Researcher 2

50%

Readers' Discipline

Tooltip

Medicine and Dentistry 4

80%

Immunology and Microbiology 1

20%

Save time finding and organizing research with Mendeley

Sign up for free