Alternative splicing of a protein domain indispensable for function of transient receptor potential melastatin 3 (TRPM3) ion channels

Abstract

Background: TRPM3 proteins form Ca2+ permeable ion channels involved in insulin secretion and pain perception. Results: A domain indispensable for TRPM3 channel function (ICF) is subject to alternative splicing. Conclusion: This domain contributes essentially to the formation of TRPM channels and removing it by splicing modulates TRPM3-mediated Ca 2+ signaling. Significance: Alternative splicing of the ICF domain regulates biological functions attributed to TRPM3. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.