Halogenated Bianthrones From Penicillium roseopurpureum: a Fungal Endophyte of the Marine Alga Petalonia fascia

Abstract

An extract of the fungus Penicillium roseopurpureum (KP1-135C) isolated from the marine alga Petalonia fascia showed selective antimicrobial activity against Staphylococcus aureus and Mycobacterium tuberculosis H37Ra. Bioassay-guided fractionation revealed that three halogenated bianthrones, neobulgarone D, neobulgarone E, and neobulgarone F, were responsible for the observed activity of the extract. The stereochemistry of the neobulgarones was unambiguously assigned based on polarimetric data and the analysis of 1H-nuclear magnetic resonance data obtained for the three bianthrones.