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Rational Approach to Stable, Universal Somatostatin Analogues with Superior Therapeutic Potential

  • Lewis I
  • Bauer W
  • Albert R
  • et al.
Springer Netherlands, (2001), 716-718
DOI: 10.1007/978-94-010-0464-0_334
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Abstract

The use of a rational approach based on structure-activity relationships led to the discovery of SOM230, a novel and stable cyclohexapeptide somatostatin analog. SOM230 exhibited unique high affinity binding to human somatostatin receptors (SSTR1-5) and a superior inhibitory effect on the GH and IGF-1. [on SciFinder (R)]

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APA

Lewis, I., Bauer, W., Albert, R., Chandramouli, N., Pless, J., Engel, G., … Bruns, C. (2001). Rational Approach to Stable, Universal Somatostatin Analogues with Superior Therapeutic Potential. In Peptides: The Wave of the Future (pp. 716–718). Springer Netherlands. https://doi.org/10.1007/978-94-010-0464-0_334

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