Sn-117m is a theragnostic isotope of increasing interest. It has ideal imaging and therapeutic properties for many applications. Production of high specific activity Sn-117m can only be achieved with accelerators and the Sb(p,x) and Cd-116(α,3n) reactions provide the highest yields for this isotope. This paper describes the production and a new purification method for obtaining commercial quantities of Sn-117m via the Cd-116(α,3n) reaction. The purified Sn-117m has subsequently been chelated with an aminobenzyl derivative of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and then conjugated with annexin V-128 to produce an agent for the diagnosis and treatment of vulnerable plaque.
CITATION STYLE
Stevenson, N. R., George, G. S., Simón, J., Srivastava, S. C., Mueller, D. W., Gonzales, G. R., … Horn, I. M. (2015). Methods of producing high specific activity Sn-117m with commercial cyclotrons. Journal of Radioanalytical and Nuclear Chemistry, 305(1), 99–108. https://doi.org/10.1007/s10967-015-4031-7
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