Increase of 3-hydroxykynurenine (3-HKYN) concentration was observed in plasma patients with chronic renal insufficiency (CRI). These changes positively correlated with the concentration of creatinine, but negatively correlated with haematological parameters: haematocrit, haemoglobin and red blood cells count. The changes were accompanied by a slight decrease of the concentration of erythropoietin (EPO) in plasma of patients with CRI. The "in vitro" study in the conditions of hypoxia showed that 3-HKYN inhibited the release of EPO from HepG2 cells to the culture base. In conclusion, the erythropoiesis in CRI could be attributed to the influence of 3-HKYN on EPO synthesis. Thus, we propose that 3-HKYN can be an uraemic of toxin partially responsible for anaemia patients with CRI.
CITATION STYLE
Pawlak, D., Koda, M., Wołczyński, S., Myśliwiec, M., & Buczko, W. (2003). Mechanism of inhibitory effect of 3-hydroxykynurenine on erythropoiesis in patients with renal insufficiency. In Advances in Experimental Medicine and Biology (Vol. 527, pp. 375–380). Kluwer Academic/Plenum Publishers. https://doi.org/10.1007/978-1-4615-0135-0_43
Mendeley helps you to discover research relevant for your work.