Bi-exponential T2*analysis of healthy and diseased Achilles tendons: An in vivo preliminary magnetic resonance study and correlation with clinical score

Abstract

Objective: To compare mono- and bi-exponential T2*analysis in healthy and degenerated Achilles tendons using a recently introduced magnetic resonance variable-echo-time sequence (vTE) for T2* mapping. Methods: Ten volunteers and ten patients were included in the study. A variable-echo-time sequence was used with 20 echo times. Images were post-processed with both techniques, mono- and bi-exponential [T 2*m, short T2*component (T 2*s) and long T2*component (T 2*l)]. The number of mono- and bi-exponentially decaying pixels in each region of interest was expressed as a ratio (B/M). Patients were clinically assessed with the Achilles Tendon Rupture Score (ATRS), and these values were correlated with the T2*values. Results: The means for both T2*m and T2* s were statistically significantly different between patients and volunteers; however, for T2*s, the P value was lower. In patients, the Pearson correlation coefficient between ATRS and T 2*s was -0.816 (P = 0.007). Conclusion: The proposed variable-echo-time sequence can be successfully used as an alternative method to UTE sequences with some added benefits, such as a short imaging time along with relatively high resolution and minimised blurring artefacts, and minimised susceptibility artefacts and chemical shift artefacts. Bi-exponential T 2*calculation is superior to mono-exponential in terms of statistical significance for the diagnosis of Achilles tendinopathy. Key Points: • Magnetic resonance imaging offers new insight into healthy and diseased Achilles tendons • Bi-exponential T2*calculation in Achilles tendons is more beneficial than mono-exponential • A short T2*component correlates strongly with clinical score • Variable echo time sequences successfully used instead of ultrashort echo time sequences © 2013 The Author(s).