Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat

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Abstract

A genome-wide quantitative trait loci analysis for blood pressure was performed using 107 male F2 rats derived from Dahl salt-sensitive and Lewis rats. Blood pressure was assessed by telemetry, and >400 microsatellite markers were used for genotyping. Two major quantitative trait loci for blood pressure were identified at chromosome 1 and chromosome 10. The expression levels of 366 transcripts around the chromosome 1 quantitative trait loci were assessed by RT-PCR, and we found that the Klk1 (kallikrein 1) and Ngfg (nerve growth factor gamma) mRNA levels were significantly reduced in the kidneys of Dahl salt-sensitive rats compared with those in Lewis rats. The expression levels of kallikrein 1 protein were also suppressed in Dahl salt-sensitive rats compared with those in Lewis rats. Because the kallikrein-kinin system has been shown to be involved in renal function, including salt homeostasis, it is likely that the reduced expression of Klk1 contributes to salt-sensitive hypertension in Dahl salt-sensitive rats. © 2005 American Heart Association, Inc.

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Iwai, N., Yasui, N., Naraba, H., Tago, N., Yamawaki, H., & Sumiya, H. (2005). Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat. Hypertension, 45(5), 947–953. https://doi.org/10.1161/01.HYP.0000161969.65767.0d

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