Effects of long-term administration of IGF-I on the adipose tissue and carbohydrate metabolism in children with Laron syndrome

Abstract

Long-term treatment with IGF-I of children with Laron syndrome caused a transitory reduction in serum cholesterol and subcutaneous skinfolds but subsequently the values of cholesterol started to rise and so the degree of adipose tissue. The effects on the carbohydrate metabolism were a reduction in serum insulin concentration resulting in a relative rise of glucose, preventing hypoglycemia. © Springer-Verlag Berlin Heidelberg 2011.