Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes

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Abstract

Antimycobacterially active salicylanilide diethyl phosphates were evaluated to identify their potential drug target(s) for the inhibition of several mycobacterial enzymes, including isocitrate lyase, L-alanine dehydrogenase (MtAlaDH), lysine ε-aminotransferase, chorismate mutase, and pantothenate synthetase. The enzymes are related to the nongrowing state of Mycobacterium tuberculosis. Salicylanilide diethyl phosphates represent new candidates with significant inhibitory activity especially against L-alanine dehydrogenase. The most active MtAlaDH inhibitor, 5-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl diethyl phosphate, has an IC50 of 4.96 μM and the best docking results. Other mycobacterial enzymes were mostly inhibited by some derivatives but at higher concentrations; isocitrate lyase showed the highest resistance to salicylanilide diethyl phosphates.

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Krátký, M., Novotná, E., Saxena, S., Yogeeswari, P., Sriram, D., Švarcová, M., & Vinšová, J. (2014). Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes. Scientific World Journal, 2014. https://doi.org/10.1155/2014/703053

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