A probabilistic atlas of the human motion complex built from large-scale functional localizer data

Abstract

Accurate motion perception is critical to dealing with the changing dynamics of our visual world. A cluster known as the human MT+ complex (hMT+) has been identified as a core region involved in motion perception. Several atlases defined based on cytoarchitecture, retinotopy, connectivity, and multimodal features include homologs of the hMT+. However, an hMT+ atlas defined directly based on this region's response for motion is still lacking. Here, we identified the hMT+ based on motion responses from functional magnetic resonance imaging (fMRI) localizer data in 509 participants and then built a probabilistic atlas of the hMT+. As a result, four main findings were revealed. First, the hMT+ showed large interindividual variability across participants. Second, the atlases stabilized when the number of participants used to build the atlas was more than 100. Third, the functional hMT+ showed good agreement with the hMT+ atlases built based on cytoarchitecture, retinotopy, and connectivity, suggesting a good structural–functional correspondence. Fourth, tests on multiple fMRI data sets acquired from independent participants, imaging parameters and paradigms revealed that the functional hMT+ showed higher sensitivity than all other atlases in ROI analysis except that connectivity and multimodal hMT+ atlases in the left hemisphere could infrequently attain comparable sensitivity to the functional atlas. Taken together, our findings reveal the benefit of using large-scale functional localizer data to build a reliable and representative hMT+ atlas. Our atlas is freely available for download; it can be used to localize the hMT+ in individual participants when functional localizer data are not available.