Calcium signalling system controls majority of cellular reactions. Calcium signals occurring within tightly regulated temporal and spatial domains, govern a host of Ca2+- dependent enzymes, which in turn determine specified cellular responses. Generation of Ca2+ signals is achieved through coordinated activity of several families of Ca2+ channels and transporters differentially distributed between intracellular compartments. Cell damage induced by environmental insults or by overstimulation of physiological pathways results in pathological Ca2+ signals, which trigger necrotic or apoptotic cellular death.
CITATION STYLE
Verkhratsky, A. (2007). Calcium and cell death. Subcellular Biochemistry, 45, 465–480. https://doi.org/10.1007/978-1-4020-6191-2_17
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