Relationship between chronic periodontitis and lower urinary tract symptoms/benign prostatic hyperplasia

Abstract

Purpose: We investigated the relationship between lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) and chronic periodontitis (CP). Methods: A total of 103 middle-aged men who had received a health checkup were included. All participant data were prospectively collected. CP was defined as a 30% increase in the number of probed sites with a clinical attachment level of ≥4 mm among all probed sites. LUTS/BPH were assessed using transrectal ultrasonography, the International Prostate Symptom Score (IPSS), uroflowmetry, and postvoiding residual urine volume. Results: The median age, IPSS, prostate volume, and maximal flow rate were 55.0 years, 9.0, 29.0 mL, and 20.0 mL/sec, respectively. In addition, the prevalence of CP was 27.2%. The IPSS total, IPSS voiding, IPSS storage, and quality of life (QoL) scores were significantly higher in patients with CP (median [interquartile range, IQR].IPSS total: 8.0 [5.0.13.5] vs. 12.0 [7.5.20.5], P=0.004; IPSS voiding: 5.0 [2.0.9.0] vs. 8.5 [4.0.15.0], P=0.002; IPSS storage: 3.0 [2.0.5.0] vs. 4.0 [3.0.6.0], P=0.021; QoL: 2.0 [1.0.3.0] vs. 3.0 [2.0.4.0], P=0.015). Additionally, the average flow rate was significantly lower in patients with CP (median [IQR] (mL/sec): 9.0 [8.0.13.0] vs. 8.0 [6.0.11.0], P=0.047). After adjustment for age, testosterone level, prostate volume, glucose level, cholesterol level, and waist circumference, the IPSS total and voiding scores were significantly and positively related to CP (IPSS total: odds ratio [OR], 1.141; 95% confidence interval [CI], 1.045.1.245; P=0.003; IPSS voiding: OR, 1.243; 95% CI, 1.092.1.415; P=0.001). Conclusions: Our data suggest that LUTS/BPH is significantly related to CP.