Histiocitosis de células de Langerhans pulmonar. Caso clínico

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Abstract

Adult pulmonary Langerhans cell histiocytosis (PLCH) is a rare disorder of unknown etiology that occurs predominantly in young smokers, with an incidence peak at 20-40 years of age. In adults, pulmonary involvement with Langerhans cell histiocytosis usually occurs as a single-organ disease and is characterized by focal Langerhans cell granulomas infiltrating and destroying distal bronchioles. We report a 23-year-old asymptomatic male smoker with a non-specific interstitial infiltrate found in preventive chest X ray examination. A high resolution chest CT scan showed multiple cystic structures predominating in the upper lobes, with small centrilobular nodules. A transbronchial biopsy showed a lymphocytic lung infiltrate with Langerhans cells. A surgical biopsy confirmed the diagnosis of pulmonary Langerhans cell histiocytosis. After six months of follow up, the patient is in good conditions.

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Rodrigo, O. A., Sergio, G. B., Marcia, A. Z., & Fernando, S. P. (2011). Histiocitosis de células de Langerhans pulmonar. Caso clínico. Revista Medica de Chile, 139(2), 230–235. https://doi.org/10.4067/S0034-98872011000200014

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